| Cocaine, lidocaine, tetracaine: which is best for topical nasal anesthesia? | |
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MedLine Citation:
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PMID: 7574001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The quality of nasal anesthesia obtained with three local anesthetic solutions (4% cocaine, 2% lidocaine in oxymetazoline, and 1% tetracaine in oxymetazoline) was evaluated in a randomized study. Each local anesthetic mixture was applied to the nasal septum of healthy volunteers using medication-soaked pledgets. Measurements of anesthetic effect (sensation threshold and pain perception) were made with Semmes-Weinstein monofilaments. Measurements were performed prior to local anesthetic application and 10 and 70 min after local anesthetic application. Subjects had greater increases in sensation threshold with tetracaine than with lidocaine or cocaine at both 10 and 70 min (P < 0.05). Subjects had greater decreases in pain perception with tetracaine than with lidocaine or cocaine at both time intervals (P < 0.05). Tetracaine mixed with oxymetazoline appears to be a superior topical anesthetic for nasal procedures. |
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Authors:
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A D Noorily; S H Noorily; R A Otto |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 81 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-06 Completed Date: 1995-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 724-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center, San Antonio 78284-7838, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, Local* Anesthetics, Local* Cocaine* Humans Lidocaine* Male Middle Aged Nose* Pain Measurement Pain Threshold Tetracaine* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 137-58-6/Lidocaine; 50-36-2/Cocaine; 94-24-6/Tetracaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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