Document Detail

Cocaine, lidocaine, tetracaine: which is best for topical nasal anesthesia?
MedLine Citation:
PMID:  7574001     Owner:  NLM     Status:  MEDLINE    
The quality of nasal anesthesia obtained with three local anesthetic solutions (4% cocaine, 2% lidocaine in oxymetazoline, and 1% tetracaine in oxymetazoline) was evaluated in a randomized study. Each local anesthetic mixture was applied to the nasal septum of healthy volunteers using medication-soaked pledgets. Measurements of anesthetic effect (sensation threshold and pain perception) were made with Semmes-Weinstein monofilaments. Measurements were performed prior to local anesthetic application and 10 and 70 min after local anesthetic application. Subjects had greater increases in sensation threshold with tetracaine than with lidocaine or cocaine at both 10 and 70 min (P < 0.05). Subjects had greater decreases in pain perception with tetracaine than with lidocaine or cocaine at both time intervals (P < 0.05). Tetracaine mixed with oxymetazoline appears to be a superior topical anesthetic for nasal procedures.
A D Noorily; S H Noorily; R A Otto
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  81     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-06     Completed Date:  1995-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  724-7     Citation Subset:  AIM; IM    
Department of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center, San Antonio 78284-7838, USA.
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MeSH Terms
Anesthesia, Local*
Anesthetics, Local*
Middle Aged
Pain Measurement
Pain Threshold
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine; 50-36-2/Cocaine; 94-24-6/Tetracaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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