Document Detail

Cocaine-induced ventricular fibrillation: protection afforded by the calcium antagonist verapamil.
MedLine Citation:
PMID:  3181653     Owner:  NLM     Status:  MEDLINE    
There is increasing evidence that the use of cocaine can trigger lethal cardiac events, including ventricular fibrillation. The mechanism responsible for these lethal cardiac arrhythmias remains to be determined. Therefore, 13 mongrel dogs were instrumented so that heart rate, left ventricular pressure (LVP), and d(LVP)/dt could be measured. After a 3- to 4-wk recovery period, the left circumflex coronary artery was occluded for 2 min, beginning with the last minute of an exercise stress test and continuing for 1 min after the cessation of exercise. None of the dogs developed cardiac arrhythmias during the control exercise plus ischemia test. On a subsequent day, the test was repeated after the injection of cocaine HCl (1.0 mg/kg). Cocaine significantly (P less than 0.01) elevated heart rate, systolic LVP, and d(LVP)/dt, and it elicited cardiac arrhythmias in 12 of the 13 animals during the exercise plus test. In fact, 11 animals developed ventricular fibrillation. Verapamil, a calcium channel antagonist (250 micrograms/kg), attenuated the hemodynamic effects of cocaine and prevented the development of ventricular arrhythmias. These data suggest that cocaine can induce ventricular fibrillation during myocardial ischemia and that these lethal arrhythmias may be prevented by a calcium channel antagonist.
G E Billman; R S Hoskins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  2     ISSN:  0892-6638     ISO Abbreviation:  FASEB J.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-15     Completed Date:  1988-12-15     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2990-5     Citation Subset:  IM    
Department of Physiology, Ohio State University, Columbus 43210.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced
Blood Flow Velocity
Blood Pressure
Cocaine / adverse effects*
Heart Rate
Physical Exertion
Tape Recording
Ventricular Fibrillation / chemically induced,  prevention & control*
Verapamil / therapeutic use*
Grant Support
Reg. No./Substance:
50-36-2/Cocaine; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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