| Cocaine-induced oscillation is conditionable. | |
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MedLine Citation:
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PMID: 10418787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have recently shown that under some circumstances, sensitization produced by a stimulant such as cocaine (COC) can give way, with successive drug administrations, to alternating attenuations and reinstatements of the effect, an outcome that we have termed oscillation. Because sensitization to COC can be conditioned, we inquired whether COC-induced oscillation also was conditionable. The end point used was shock-induced hypoalgesia (paw withdrawal from a hot plate), as we have previously shown that oscillation follows initial sensitization of this measure with one to five pretreatments of 12 mg/kg (IP) of COC spaced at 1-week intervals, with the last COC injection occurring 30 min prior to the footshock. Experiment 1 indicated that a conditioned stimulus (CS)--a distinctive environment--which repeatedly had been paired with COC, would substitute for the last COC injection in sustaining the oscillatory effect. Experiment 2 showed that a previously established CS successfully substituted for all COC injections in first inducing sensitization that was then followed by oscillation. These findings strongly suggest that COC-induced oscillation shares with COC-induced sensitization, the property that both can be conditioned. |
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Authors:
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B J Kucinski; S M Antelman; A R Caggiula; H Fowler; S Gershon; D J Edwards |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 63 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-14 Completed Date: 1999-09-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 449-55 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Pittsburgh, PA 15213, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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pharmacology* Animals Cocaine / pharmacology* Conditioning, Operant / drug effects, physiology Cues Dopamine Uptake Inhibitors / pharmacology* Electroshock Environment Male Pain Measurement / drug effects Pain Threshold / drug effects*, psychology* Rats Rats, Sprague-Dawley Reaction Time / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DA09163/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine |
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