Document Detail

Cocaine-induced oscillation is conditionable.
MedLine Citation:
PMID:  10418787     Owner:  NLM     Status:  MEDLINE    
We have recently shown that under some circumstances, sensitization produced by a stimulant such as cocaine (COC) can give way, with successive drug administrations, to alternating attenuations and reinstatements of the effect, an outcome that we have termed oscillation. Because sensitization to COC can be conditioned, we inquired whether COC-induced oscillation also was conditionable. The end point used was shock-induced hypoalgesia (paw withdrawal from a hot plate), as we have previously shown that oscillation follows initial sensitization of this measure with one to five pretreatments of 12 mg/kg (IP) of COC spaced at 1-week intervals, with the last COC injection occurring 30 min prior to the footshock. Experiment 1 indicated that a conditioned stimulus (CS)--a distinctive environment--which repeatedly had been paired with COC, would substitute for the last COC injection in sustaining the oscillatory effect. Experiment 2 showed that a previously established CS successfully substituted for all COC injections in first inducing sensitization that was then followed by oscillation. These findings strongly suggest that COC-induced oscillation shares with COC-induced sensitization, the property that both can be conditioned.
B J Kucinski; S M Antelman; A R Caggiula; H Fowler; S Gershon; D J Edwards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  63     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  449-55     Citation Subset:  IM    
Department of Psychology, University of Pittsburgh, PA 15213, USA.
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MeSH Terms
Anesthetics, Local / pharmacology*
Cocaine / pharmacology*
Conditioning, Operant / drug effects,  physiology
Dopamine Uptake Inhibitors / pharmacology*
Pain Measurement / drug effects
Pain Threshold / drug effects*,  psychology*
Rats, Sprague-Dawley
Reaction Time / drug effects
Grant Support
Reg. No./Substance:
0/Anesthetics, Local; 0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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