Document Detail


Cocaine-induced inhibition of process outgrowth in locus coeruleus neurons: role of gestational exposure period and offspring sex.
MedLine Citation:
PMID:  15380829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cocaine use during pregnancy is associated with neurobehavioral problems in school-aged children that implicate alterations in attentional processes, potentially due to impairments in the noradrenergic system. We analyzed locus coeruleus (LC) neurite outgrowth characteristics following the administration of a physiologically relevant dose of cocaine (3.0 mg/kg) issued during critical phases of gestation (gestational day (GD)8-14, GD15-21, GD8-21). Results showed that cocaine inhibits LC neurite outgrowth and development, as evidenced by a decrease in total neurite length, a decrease in neurite length per cell, and a decrease in the percentage of cells with neurites. Morphological differences between cultures treated with and without cocaine were also evident. Further, the specific gestational exposure period effects were also dependent upon sex of the fetus. Finally, a discriminant function analysis suggested that the pattern and magnitude of alterations that defined the GD8-14 exposure were significantly different from that of the GD15-21 or GD8-21 exposures. Collectively, these data demonstrate a direct, disruptive effect of cocaine on noradrenergic neurons and may provide a neurobiological basis for changes in attentional function seen in offspring exposed to cocaine in utero.
Authors:
Diane M Snow; Heidi M Carman; Jeffrey D Smith; Rosemarie M Booze; Marian A Welch; Charles F Mactutus
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  22     ISSN:  0736-5748     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:    2004 Aug-Oct
Date Detail:
Created Date:  2004-09-21     Completed Date:  2004-12-02     Revised Date:  2013-10-18    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  297-308     Citation Subset:  IM    
Affiliation:
The University of Kentucky, Department of Anatomy and Neurobiology, Willard Medical Center-MN212, 800 Rose Street, Lexington, KY 40536-0298, USA. dsnow@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Attention / drug effects
Cocaine / administration & dosage*
Dose-Response Relationship, Drug
Female
Gestational Age
Injections, Intravenous
Locus Coeruleus / cytology*,  drug effects*
Male
Maternal-Fetal Exchange / physiology
Neurites / drug effects*,  ultrastructure*
Neurons / cytology,  drug effects
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Rats, Long-Evans
Sex Factors
Grant Support
ID/Acronym/Agency:
DA09160/DA/NIDA NIH HHS; DA12719/DA/NIDA NIH HHS; DA13137/DA/NIDA NIH HHS; DA14401/DA/NIDA NIH HHS; HD043680/HD/NICHD NIH HHS; R01 DA012719/DA/NIDA NIH HHS; R01 DA013137/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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