Document Detail

Cocaine-induced hypertension: role of the peripheral sympathetic system.
MedLine Citation:
PMID:  10433872     Owner:  NLM     Status:  MEDLINE    
Cocaine causes hypertension at least in part by stimulating the sympathetic nervous system, but it is not clear if this effect is centrally or peripherally mediated. To address this issue we studied the vasoconstrictive effect of cocaine in vivo and in isolated artery segments. In vivo cocaine increased mean arterial blood pressure (MAP) by 40 mmHg within 1 min of administration. Pretreatment with prazosin blocked this response by 62%. With clonidine the pre-cocaine MAP was lower and the hypertensive effect of cocaine was blocked by 50%, indicating an important role for central alpha-adrenergic mechanisms. In isolated rat carotid arteries cocaine-induced vasoconstriction was completely blocked by prazosin, phentolamine, and 6-hydroxydopamine, indicating a clear role for a peripheral effect. However, the relative contribution of the central alpha-adrenergic mechanism to the total vasoconstrictive response of cocaine was not clarified. 1999 Academic Press.
W Mo; J A Arruda; G Dunea; A K Singh
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  40     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-08     Completed Date:  1999-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Hektoen Institute for Medical Research, 627 South Wood Street, Chicago, IL 60612, USA.
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MeSH Terms
Adrenergic Agents / pharmacology
Adrenergic alpha-Antagonists / pharmacology
Blood Pressure / drug effects
Carotid Arteries / drug effects,  innervation,  physiopathology
Cocaine / pharmacology*
Hypertension / chemically induced,  physiopathology*
Oxidopamine / pharmacology
Phentolamine / pharmacology
Rats, Sprague-Dawley
Sympathetic Nervous System / physiopathology
Vasoconstriction / drug effects
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Adrenergic Agents; 0/Adrenergic alpha-Antagonists; 0/Vasoconstrictor Agents; 1199-18-4/Oxidopamine; 50-36-2/Cocaine; 50-60-2/Phentolamine

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