| Cocaine-induced cardiovascular effects: lack of evidence for a central nervous system site of action based on hemodynamic studies with cocaine methiodide. | |
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MedLine Citation:
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PMID: 9890394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that cocaine acts directly in the brain to enhance central sympathetic outflow. However, some studies suggested that the cardiovascular effects of cocaine are related to a peripheral action. To characterize further the site of cocaine's cardiovascular effect, we compared the hemodynamic effects of cocaine (2 mg/kg, i.v. bolus) with those observed after administration of an equimolar dose (2.62 mg/kg, i.v. bolus) of cocaine methiodide, a quaternary derivative of cocaine that does not penetrate the blood-brain barrier, by using sufentanil-sedated dogs. Cocaine produced significant (p < 0.05) increases in heart rate (+37+/-11 beats/min), mean arterial pressure (+55+/-11 mm Hg), left ventricular end-diastolic pressure (+5.3+/-1.0 mm Hg), and cardiac output (+2.4+/-0.9 L/min). Cocaine methiodide produced increases in heart rate (+57+/-11 beats/min), mean arterial pressure (+45+/-11 mm Hg), left ventricular end-diastolic pressure (+3.4+/-1.0 mm Hg), and cardiac output (1.1+/-0.9 L/min), which were not significantly different from those observed with cocaine. Because opiate sedation potentially might have attenuated central sympathetic outflow, we further confirmed the qualitative similarity of the actions of cocaine and cocaine methiodide on heart rate and blood pressure in unsedated, conscious dogs. Our data suggest that the cardiovascular effects of cocaine result primarily from a peripheral site of action. |
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Authors:
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L W Dickerson; D J Rodak; F E Kuhn; S K Wahlstrom; R E Tessel; M S Visner; G L Schaer; R A Gillis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 33 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-03-11 Completed Date: 1999-03-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 36-42 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20007, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Intravenous Animals Blood Pressure / drug effects* Central Nervous System / drug effects* Cocaine / analogs & derivatives*, pharmacology Dogs Electrocardiography / drug effects Heart Rate / drug effects* Male Sufentanil Vasoconstrictor Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA-05333/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Vasoconstrictor Agents; 50-36-2/Cocaine; 56030-54-7/Sufentanil; 5937-29-1/cocaine methiodide |
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