Document Detail

Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding.
MedLine Citation:
PMID:  1870807     Owner:  NLM     Status:  MEDLINE    
A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage. Cocaine and indomethacin may act synergistically to adversely affect renal, cardiovascular, and platelet function. It may be prudent to obtain a drug history and urine screen for cocaine before instituting indomethacin therapy for preterm labor or polyhydramnios.
S J Carlan; C Stromquist; J L Angel; M Harris; W F O'Brien
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  78     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-16     Completed Date:  1991-09-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  501-3     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa.
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MeSH Terms
Anuria / chemically induced*
Cocaine* / adverse effects
Drug Synergism
Fetal Diseases / chemically induced*
Gastrointestinal Hemorrhage / chemically induced
Indomethacin / administration & dosage,  adverse effects*
Infant, Newborn
Maternal-Fetal Exchange
Obstetric Labor, Premature / drug therapy*
Polyhydramnios / chemically induced
Substance-Related Disorders / complications*
Reg. No./Substance:
50-36-2/Cocaine; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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