| Cocaine exposure decreases GABA neuron migration from the ganglionic eminence to the cerebral cortex in embryonic mice. | |
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MedLine Citation:
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PMID: 15054047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recurrent exposure of the developing fetus to cocaine produces persistent alterations in structure and function of the cerebral cortex. Neurons of the cerebral cortex are derived from two sources: projection neurons from the neuroepithelium of the dorsal pallium and interneurons from the ganglionic eminence of the basal telencephalon. The interneurons are GABAergic and reach the cerebral cortex via a tangential migratory pathway. We found that recurrent, transplacental exposure of mouse embryos to cocaine from embryonic day 8 to 15 decreases tangential neuronal migration and results in deficits in GABAergic neuronal populations in the embryonic cerebral wall. GABAergic neurons of the olfactory bulb, which are derived from the ganglionic eminence via the rostral migratory pathway, are not affected by the cocaine exposure suggesting a degree of specificity in the effects of cocaine on neuronal migration. Thus, one mechanism by which prenatal cocaine exposure exerts deleterious effects on cerebral cortical development may be by decreasing GABAergic neuronal migration from the ganglionic eminence to the cerebral wall. The decreased GABA neuron migration may contribute to persistent structural and functional deficits observed in the exposed offspring. |
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Authors:
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James E Crandall; Hazel E Hackett; Stuart A Tobet; Barry E Kosofsky; Pradeep G Bhide |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2004-03-28 |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: 14 ISSN: 1047-3211 ISO Abbreviation: Cereb. Cortex Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-12 Completed Date: 2004-07-06 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: United States |
Other Details:
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Languages: eng Pagination: 665-75 Citation Subset: IM |
Affiliation:
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E.K. Shriver Center for Mental Retardation, University of Massachusetts Medical School, Waltham, MA 02452, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement / drug effects, physiology* Cerebral Cortex / cytology, drug effects, embryology*, physiology* Cocaine / pharmacology* Dose-Response Relationship, Drug Median Eminence / cytology, drug effects, embryology*, physiology* Mice Neurons / drug effects, physiology* Olfactory Bulb / cytology, drug effects, embryology, physiology gamma-Aminobutyric Acid / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DA 00354/DA/NIDA NIH HHS; DA 08648/DA/NIDA NIH HHS; HD 05515/HD/NICHD NIH HHS; MH57748/MH/NIMH NIH HHS; NS 43426/NS/NINDS NIH HHS; R01 NS043426-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 56-12-2/gamma-Aminobutyric Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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