Document Detail

Cocaine decreases self-control in rats: a preliminary report.
MedLine Citation:
PMID:  1365666     Owner:  NLM     Status:  MEDLINE    
Cocaine abuse is often associated with behavior that takes into account short-term, but not long-term consequences. However, there has been no empirical research concerning the effects of cocaine on self-control (choice of a larger, more delayed reinforcer over a smaller, less delayed reinforcer). In the present research, when food-deprived rats repeatedly chose between a larger, more delayed food reinforcer and a smaller, less delayed food reinforcer, chronic intraperitoneal injections of 15 mg/kg cocaine (but not 10 mg/kg fluoxetine) decreased the rats' choices of the larger, more delayed reinforcer. Cocaine can decrease rats' self-control.
A W Logue; H Tobin; J J Chelonis; R Y Wang; N Geary; S Schachter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  109     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1992  
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Department of Psychology, State University of New York at Stony Brook 11794.
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MeSH Terms
Cocaine / administration & dosage,  pharmacology*
Conditioning, Operant / drug effects*
Fluoxetine / administration & dosage,  pharmacology
Injections, Intraperitoneal
Reinforcement (Psychology)
Reg. No./Substance:
50-36-2/Cocaine; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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