Document Detail


Cocaine causes atrial Purkinje fiber damage.
MedLine Citation:
PMID:  20192706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Comparisons of atrial tissues from Syrian hamster offspring born from cocaine-treated mothers during the last days of pregnancy with sham-treated ones demonstrate irreversible focal ischemic damage in the Purkinje myofibers and minor endocardial damages as well as minute cardiomyocyte vacuolization. These defects are consistent with the pharmacotoxicity of cocaine or its metabolites. The damaged Purkinje myocytes apparently remain in contact with adjacent cardiomyocytes but undergo autolytic process similar to that found in autoschizic cell death. Adjacent cell type(s) appear to segregate or engulf the injured cells. Data collected in this report demonstrate why clinical bradyarrhythmias, arrhythmias, or sudden death as cardiac arrest can be found in pre- and postnatal cocaine-abused babies as well as those found in young individuals caused by acute or chronic cocaine abuse.
Authors:
Jacques Gilloteaux; Nelson N Ekwedike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrastructural pathology     Volume:  34     ISSN:  1521-0758     ISO Abbreviation:  Ultrastruct Pathol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  90-8     Citation Subset:  IM    
Affiliation:
Department of Anatomical Sciences, St Georges' University School of Medicine, K B Taylor Global Scholar's Programme, Newcastle upon Tyne, UK. jgilloteaux@sgu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / toxicity*
Cricetinae
Disease Models, Animal
Female
Heart Atria / drug effects*,  pathology
Longevity / drug effects
Male
Maternal-Fetal Exchange
Mesocricetus
Microscopy, Electron, Transmission
Myocytes, Cardiac / drug effects*,  ultrastructure
Pregnancy
Purkinje Fibers / drug effects*,  ultrastructure
Vasoconstrictor Agents / toxicity*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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