Document Detail


Cocaine and cardiovascular function in dogs: effects on heart and peripheral circulation.
MedLine Citation:
PMID:  3367008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of cocaine on the heart and peripheral circulation were examined in seven mongrel dogs. Hemodynamic variables, in addition to data on ventricular relaxation, mean circulatory filling pressure and arterial compliance, were measured during an intravenous infusion (0.5 mg/kg per min) of cocaine. Holter monitor recordings (6 h) and coronary arteriograms were also obtained. Cocaine increased (p less than 0.01) mean aortic pressure from 72 +/- 5 to 92 +/- 5, left ventricular systolic pressure from 102 +/- 3 to 121 +/- 5, left ventricular end-diastolic pressure from 4.9 +/- 1.3 to 8.2 +/- 1.4 and mean circulatory filling pressure from 7.9 +/- 0.4 to 10.9 +/- 0.5 mm Hg. Cardiac index and stroke volume decreased (p less than 0.01) from 166 +/- 17 to 125 +/- 8 ml/min per kg and from 44 +/- 4 to 29 +/- 3 ml, respectively. Ejection fraction decreased (p less than 0.01) from 61 +/- 1 to 49 +/- 3%. Heart rate, first derivative of left ventricular pressure (dP/dt) and right atrial, mean pulmonary artery and pulmonary artery wedge pressures did not change. The result was a 58% increase in systemic vascular resistance and a 32% decrease in arterial compliance. The pressure gradient for venous return did not change, but resistance to venous return increased 42%. Cocaine prolonged (p less than 0.05) the half-time of left ventricular isovolumic relaxation from 13.4 +/- 0.8 to 16.4 +/- 0.8 ms and the time constant of left ventricular isovolumic relaxation from 19.3 +/- 1.2 to 23.6 +/- 1.1 ms.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J B Bedotto; R W Lee; L D Lancaster; M Olajos; S Goldman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  11     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-20     Completed Date:  1988-06-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1337-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Veterans Administration Medical Center, Tucson, Arizona 85723.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / drug effects
Blood Circulation / drug effects*
Blood Volume / drug effects
Cardiac Output / drug effects
Cocaine / administration & dosage,  pharmacology*
Coronary Vessels / drug effects
Dogs
Heart / drug effects*
Injections, Intravenous
Splenectomy
Vasoconstriction / drug effects
Grant Support
ID/Acronym/Agency:
HL-20984/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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