| Cocaine-associated myocardial infarction. | |
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MedLine Citation:
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PMID: 8795497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial ischaemia and infarction has become a well-recognized sequelae of cocaine use. The possibility of recent cocaine use should be assessed in patients with potential myocardial ischaemia because the treatment of patients with myocardial ischaemia related to cocaine differs from that of patients with myocardial ischaemia unrelated to cocaine. Patients with cocaine-associated myocardial ischaemia should receive initial treatment with benzodiazepines to decrease central adrenergic stimulation. Aspirin should be used to reduce thrombus formation, and nitroglycerin to reverse coronary vasoconstriction. Patients with continued ischaemia can be treated with either low doses of phentolamine, or verapamil. If ischaemia continues after treatment with these agents mechanical reperfusion or thrombolytic therapy should be considered depending upon the clinical circumstances. Patients with myocardial ischaemia secondary to cocaine should not receive treatment with beta adrenergic antagonists as these agents enhance coronary vasoconstriction thereby worsening ischaemia. |
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Authors:
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J E Hollander |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of the Royal Society of Medicine Volume: 89 ISSN: 0141-0768 ISO Abbreviation: J R Soc Med Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-10-09 Completed Date: 1996-10-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802879 Medline TA: J R Soc Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 443-7 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, University Medical Center, Stony Brook, New York 11794-8350, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aspirin / therapeutic use Benzodiazepines / therapeutic use Cocaine / adverse effects* Humans Middle Aged Myocardial Infarction / chemically induced*, drug therapy Myocardial Ischemia / chemically induced Nitroglycerin / therapeutic use Platelet Aggregation Inhibitors / therapeutic use Substance-Related Disorders* Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Vasodilator Agents; 12794-10-4/Benzodiazepines; 50-36-2/Cocaine; 50-78-2/Aspirin; 55-63-0/Nitroglycerin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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