Document Detail


Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos.
MedLine Citation:
PMID:  18314190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to further test whether or not psychostimulant drugs activate CART peptide-containing cells in the nucleus accumbens, we examined the fraction of CART positive cells that co-immunostained for c-Fos after administration of saline or cocaine (10 and 25 mg/kg i.p.). There was about a 45% increase in the fraction of cells that stained for both CART and c-Fos after administration of cocaine, but there was no change in the fraction after administration of saline. Moreover, the increase was not found 24h after injection and is therefore reversible. These results support the notion that psychostimulant drugs activate CART cells in the nucleus accumbens, even under conditions where it is difficult to show a change in CART levels.
Authors:
G W Hubert; M J Kuhar
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-07
Journal Detail:
Title:  Neuropeptides     Volume:  42     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-09-19     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  339-43     Citation Subset:  IM    
Affiliation:
Division of Neuroscience, The National Yerkes Primate Research Center of Emory University, Atlanta, GA 30329, USA. ghubert@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System Stimulants / pharmacology*
Cocaine / pharmacology*
Fluorescent Antibody Technique
Immunohistochemistry
Male
Nerve Tissue Proteins / metabolism*
Nucleus Accumbens / cytology*,  drug effects,  metabolism*
Proto-Oncogene Proteins c-fos / metabolism*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DA 00418/DA/NIDA NIH HHS; DA 015162/DA/NIDA NIH HHS; DA 10732/DA/NIDA NIH HHS; DA 21056/DA/NIDA NIH HHS; RR00165/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Nerve Tissue Proteins; 0/Proto-Oncogene Proteins c-fos; 0/cocaine- and amphetamine-regulated transcript protein; 50-36-2/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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