Document Detail


Cocaine abuse in pregnancy: its evaluation through hair analysis of pathological new-borns.
MedLine Citation:
PMID:  8950288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cocaine abuse in pregnancy has been evaluated through toxicological analysis of hair from 123 pathological new-borns admitted in an intensive care division. The new-borns were affected with malformations, low gestational age, low birth weight, respiratory distress. A control group of 39 healthy new-borns was also analysed. Hair samples (about 50 mg) were enzymatically digested and directly analysed by RIA. Samples positive to the preliminary screening were extracted by SPE columns and injected in GC/MS. Results obtained showed 3 positive samples (2.4%). All cocaine babies had low gestational age, low birth weight, two of them showed heart malformation, one kidney malformation and one genital malformation. None of the control new-born resulted positive for cocaine. These results show a worrying trend of cocaine diffusion in the Italian population.
Authors:
S Strano-Rossi; M Chiarotti; A Fiori; C Auriti; G Seganti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  59     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-02     Completed Date:  1997-01-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1909-15     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, Catholic University, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cocaine* / analysis
Congenital Abnormalities
Female
Gas Chromatography-Mass Spectrometry
Hair / chemistry*
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications
Radioimmunoassay
Substance-Related Disorders / complications*
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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