Document Detail


Cocaine absorption from the nasal mucosa.
MedLine Citation:
PMID:  3400843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The absorption of cocaine from the nasal mucosa was measured by serial plasma analysis in patients who received nasal cocaine for routine nasal surgery using the modified Moffett's method. Two groups were compared: one received cocaine alone and one with adrenaline 1:1000 added. Changes in pulse rate and blood pressure were recorded in each group. The group that received intranasal cocaine and adrenaline solution had significantly lower plasma cocaine levels. There was no significant difference in cardiovascular parameters between the two groups.
Authors:
L Bromley; A Hayward
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  43     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  356-8     Citation Subset:  AIM; IM    
Affiliation:
Middlesex Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Adolescent
Adult
Anesthesia, Local
Cocaine / blood,  pharmacokinetics*
Epinephrine / pharmacology
Hemodynamics
Humans
Middle Aged
Nasal Mucosa / metabolism*
Nose / surgery
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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