| A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction. | |
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MedLine Citation:
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PMID: 20045508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In addicts drug cues attract attention, elicit approach, and motivate drug-seeking and drug-taking behavior, and addicts find it difficult to resist such cues. In preclinical studies we have found, however, that food cues acquire incentive motivational properties only in a subset of individuals. For example, a food cue becomes attractive, eliciting approach and engagement with it, and acts as an effective conditional reinforcer in some rats but not others. We asked, therefore, whether rats that have a propensity to attribute incentive salience to a food cue are the same ones that attribute incentive value to a drug (cocaine) cue. METHODS: We first used a Pavlovian conditioned approach procedure to determine which individual rats attributed incentive salience to a food cue. A second cue was then associated with the IV self-administration of cocaine. Later, the ability of the cocaine cue to maintain self-administration behavior and to reinstate self-administration after extinction was assessed. RESULTS: We report that in individuals that had a propensity to attribute incentive salience to a food cue, a cocaine cue spurred motivation to take drugs (its removal greatly diminished self-administration) and reinstated robust drug-seeking after extinction. However, in those individuals that failed to attribute incentive salience to a food cue, the cocaine cue was relatively devoid of incentive motivational properties. CONCLUSIONS: We conclude that it is possible to determine, before any drug experience, which individuals will most likely have difficulty resisting drug cues, a trait that might confer susceptibility to addiction. |
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Authors:
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Benjamin T Saunders; Terry E Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-04 |
Journal Detail:
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Title: Biological psychiatry Volume: 67 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-06-17 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 730-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychology, Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cocaine / pharmacology* Cocaine-Related Disorders / psychology* Cues* Dopamine Uptake Inhibitors / pharmacology* Extinction, Psychological Food* Individuality Male Photic Stimulation Rats Rats, Sprague-Dawley Recurrence Self Administration |
| Grant Support | |
ID/Acronym/Agency:
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R37 DA004294-22/DA/NIDA NIH HHS; R37 DA04294/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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