Document Detail

A cocaine cue acts as an incentive stimulus in some but not others: implications for addiction.
MedLine Citation:
PMID:  20045508     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In addicts drug cues attract attention, elicit approach, and motivate drug-seeking and drug-taking behavior, and addicts find it difficult to resist such cues. In preclinical studies we have found, however, that food cues acquire incentive motivational properties only in a subset of individuals. For example, a food cue becomes attractive, eliciting approach and engagement with it, and acts as an effective conditional reinforcer in some rats but not others. We asked, therefore, whether rats that have a propensity to attribute incentive salience to a food cue are the same ones that attribute incentive value to a drug (cocaine) cue.
METHODS: We first used a Pavlovian conditioned approach procedure to determine which individual rats attributed incentive salience to a food cue. A second cue was then associated with the IV self-administration of cocaine. Later, the ability of the cocaine cue to maintain self-administration behavior and to reinstate self-administration after extinction was assessed.
RESULTS: We report that in individuals that had a propensity to attribute incentive salience to a food cue, a cocaine cue spurred motivation to take drugs (its removal greatly diminished self-administration) and reinstated robust drug-seeking after extinction. However, in those individuals that failed to attribute incentive salience to a food cue, the cocaine cue was relatively devoid of incentive motivational properties.
CONCLUSIONS: We conclude that it is possible to determine, before any drug experience, which individuals will most likely have difficulty resisting drug cues, a trait that might confer susceptibility to addiction.
Benjamin T Saunders; Terry E Robinson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-01-04
Journal Detail:
Title:  Biological psychiatry     Volume:  67     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-06-17     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Cocaine / pharmacology*
Cocaine-Related Disorders / psychology*
Dopamine Uptake Inhibitors / pharmacology*
Extinction, Psychological
Photic Stimulation
Rats, Sprague-Dawley
Self Administration
Grant Support
R37 DA004294/DA/NIDA NIH HHS; R37 DA004294-22/DA/NIDA NIH HHS; R37 DA04294/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; I5Y540LHVR/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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