| Cobb syndrome in an infant: treatment with endovascular embolization and corticosteroid therapy: case report. | |
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MedLine Citation:
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PMID: 12590699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE AND IMPORTANCE: Cobb syndrome is a rare clinical entity characterized by the combination of a vascular skin nevus and an angioma in the spinal canal at the same metamere. We present a case report of an infant with Cobb syndrome. CLINICAL PRESENTATION: A 5-month-old girl presented with cutaneous hemangioma of the thoracolumbar region (T5-T12) and paraparesis. The infant was examined by magnetic resonance imaging and aortography and was diagnosed with Cobb syndrome. INTERVENTION: The patient received orally administered prednisolone therapy and underwent endovascular embolization of paravertebral and spinal angiomas with the use of n-butyl-2-cyanoacrylate. Her symptoms improved by combined treatment with liquid embolization and corticosteroid therapy. CONCLUSION: Although Cobb syndrome has been reported in older children, it is extremely rare in infants. To our knowledge, this is the first report of an infant with Cobb syndrome treated with endovascular embolization and corticosteroid therapy. The combined treatment with corticosteroid therapy and endovascular embolization of cutaneomeningospinal angioma in Cobb syndrome seems effective in alleviating symptoms and minimizing morbidity. |
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Authors:
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Akio Soeda; Nobuyuki Sakai; Koji Iihara; Izumi Nagata |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neurosurgery Volume: 52 ISSN: 0148-396X ISO Abbreviation: Neurosurgery Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-02-19 Completed Date: 2003-04-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: United States |
Other Details:
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Languages: eng Pagination: 711-5; discussion 714-5 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, National Cardiovascular Center, Osaka, Japan. ccd29400@nyc.odn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Hormonal
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therapeutic use* Embolization, Therapeutic* Female Hemangioma / complications*, therapy* Humans Infant Nevus / complications*, therapy* Prednisolone / therapeutic use* Skin Neoplasms / complications*, therapy* Spinal Canal / drug effects*, surgery* Spinal Neoplasms / complications*, therapy* Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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