Document Detail

Cobb syndrome: a case report and systematic review of the literature.
MedLine Citation:
PMID:  19027589     Owner:  NLM     Status:  MEDLINE    
We report on a case of Cobb syndrome, a rare metameric disorder, characterized by a vascular abnormality of the spinal cord, with an associated vascular skin lesion of the same metamere, in an 8-year-old girl presenting with leg weakness. Magnetic resonance imaging revealed a spinal arteriovenous malformation at the level of T(10)-L(5). This finding, together with a large, pigmented nevus at this level, is diagnostic for Cobb syndrome. A systematic review of the literature on Cobb syndrome, with a focus on treatment and outcomes, is presented. Current treatment options include combinations of embolization, neurosurgical intervention, corticosteroid therapy, and radiotherapy.
Marissa Tubridy Clark; Emma L Brooks; Winston Chong; Chris Pappas; Michael Fahey
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pediatric neurology     Volume:  39     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-5     Citation Subset:  IM    
Department of Paediatrics, Monash Medical Centre, Monash University, Melbourne, Victoria, Australia.
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MeSH Terms
Central Nervous System Vascular Malformations / complications*
Magnetic Resonance Imaging
Skin Diseases / complications*
Spinal Diseases / complications*

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