Document Detail

Cobalt-induced polycythaemia causing right ventricular hypertrophy and ascites in meat-type chickens.
MedLine Citation:
PMID:  18671074     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Cobalt increases the red cell mass in both man and animals by increasing the production of erythropoietin. Since meat-type chickens can develop pulmonary hypertension from increased erythropoiesis and polycythaemia, two trials were conducted to investigate the role of cobalt on broiler chicken erythropoiesis and pulmonary hypertension. The results showed that feeding cobaltous chloride at 500 parts/10(6) to meat-type chickens from 1-day-old for 42 days significantly increased haemoglobin content and, to a lesser extent red blood cell count, and haematocrit. No effect was observed on mean corpuscular volume. Increased haemoglobin content was linearly correlated with pulmonary hypertension as measured by the right ventricle weight to total ventricle weight ratio (RV:TV). Levels of malondialdehyde in cardiac tissue were also correlated with the RV:TV ratio, suggesting that peroxidative damage may be related to ventricular hypertrophy. Chickens fed cobalt showed a significantly higher incidence of right ventricular hypertrophy and right ventricular failure and 18.3% developed ascites.
G J Diaz; R J Julian; E J Squires
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Avian pathology : journal of the W.V.P.A     Volume:  23     ISSN:  0307-9457     ISO Abbreviation:  Avian Pathol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2009-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210638     Medline TA:  Avian Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-104     Citation Subset:  -    
Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Santafe de Bogota, Colombia.
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