Document Detail

Cobalamin deficiency associated with erythroblastic anemia and methylmalonic aciduria in a border collie.
MedLine Citation:
PMID:  10493414     Owner:  NLM     Status:  MEDLINE    
Anemia due to cobalamin deficiency is a rare genetic disorder that has been recognized in dogs only recently. This report concerns a 14-month-old border collie that presented for chronic, nonregenerative anemia. Cytological examination of a peripheral blood smear showed the presence of erythroblasts. Serum cobalamin levels were below reference ranges reported for clinically normal dogs. A methylmalonic aciduria was found on urinalysis. These signs are consistent with the anemia in Imerslund-Graesbeck syndrome reported in humans. Anemia due to cobalamin deficiency responds to parenteral vitamin B12 therapy, and affected animals have a good prognosis for recovery.
L W Morgan; J McConnell
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  35     ISSN:  0587-2871     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-10-28     Completed Date:  1999-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  392-5     Citation Subset:  IM    
Friendship Hospital for Animals, Washington, DC 20016, USA.
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MeSH Terms
Dog Diseases / diagnosis*,  urine
Methylmalonic Acid / urine*
Vitamin B 12 Deficiency / complications,  diagnosis,  veterinary*
beta-Thalassemia / complications,  diagnosis,  veterinary*
Grant Support
02512//PHS HHS
Reg. No./Substance:
516-05-2/Methylmalonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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