| Coated hydralazine hydrochloride beads for sustained release after oral administration. | |
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MedLine Citation:
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PMID: 23057650 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hydralazine hydrochloride is an antihypertensive used alone or in combination with isosorbide nitrate for the treatment of congestive heart failure. Since control of blood pressure should be continuous, sustained release delivery of this drug is considered therapeutically beneficial. Core beads for oral administration of this drug were prepared by extrusion-spheronization. Using experimental design to define the coat that was applied, the core beads were coated using a fluid bed coater to different coat thickness with combinations of two commercially available products dissolved in a hydroalcoholic solvent. The coat is a film with a combination of ethylcellulose and hydroxypropylcellulose that can provide desirable release profiles. Visually spherical and rugged bead products were obtained. Two products were identified that exhibited essentially a zero order release profile following a 2-h lag time with release of greater than 70% of the drug over the next 10 h in simulated intestinal fluid. |
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Authors:
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M Akhlaq Mughal; Kalyan K Saripella; Chahinaz Kouba; Zafar Iqbal; Steven H Neau |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: - ISSN: 1520-5762 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Philadelphia College of Pharmacy, University of the Sciences , 600 43rd Street, Philadelphia, PA 19104 , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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