Document Detail

Coat-colour dilution and hypotrichosis in Hereford crossbred calves.
MedLine Citation:
PMID:  18408794     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate cases of coat-colour dilution and hypotrichosis in a group of Hereford x Friesian crossbred calves, and to define the underlying molecular genetics of the disorder. METHODS: The investigation was predicated on the hypothesis that this disorder was similar to a known dominantly inherited disorder of calves of black breeds crossed with Simmental cattle, for which there were candidate gene mutations. Sequence analyses of PCR amplicons from exon 1 and exon 11 of the premelanosome protein 17 gene (PMel17) were carried out. Restriction enzyme digestions of amplicons were followed using electrophoresis of digested fragments. RESULTS: It was shown that an affected calf and its Hereford sire were heterozygous for a three-base deletion in exon 1 of the PMel17 gene. These two animals were also heterozygous for a second mutation in exon 11 of the PMel17 gene. Four other related animals were likewise heterozygous for both mutations in the sire's herd of origin. CONCLUSIONS: Coat-colour dilution and hypotrichosis in Hereford crossbred calves in New Zealand is the same genetic disorder as that previously described in Simmental crossbred calves, and is linked to mutations in the PMel17 gene.
R D Jolly; J L Wills; J E Kenny; J I Cahill; L Howe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  New Zealand veterinary journal     Volume:  56     ISSN:  0048-0169     ISO Abbreviation:  N Z Vet J     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-07-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0021406     Medline TA:  N Z Vet J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  74-7     Citation Subset:  IM    
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
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MeSH Terms
Animals, Newborn
Cattle / genetics
Cattle Diseases / genetics*
Crosses, Genetic
DNA / analysis
Hair Color / genetics*
Hypotrichosis / genetics,  veterinary*
Melanins / genetics*
Polymerase Chain Reaction / veterinary
Quantitative Trait Loci
Reg. No./Substance:
0/Melanins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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