Document Detail


Coarse-grained modeling of lipids.
MedLine Citation:
PMID:  19477311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molecular modeling of phospholipids on many scales has progressed significantly over the last years. Here we review several membrane models on intermediate to large length scales restricting ourselves to particle based coarse-grained models with implicit and explicit solvent. We explain similarities and differences as well as their connection to experiments and fine-grained models. We neglect any field descriptions on larger scales. We discuss then a few examples where we focus on studies of lipid phase behavior as well as supported lipid bilayers as these examples can only be meaningfully studied using large-scale models to date.
Authors:
Sandra V Bennun; Matthew I Hoopes; Chenyue Xing; Roland Faller
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2009-04-02
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  159     ISSN:  1873-2941     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-29     Completed Date:  2009-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Affiliation:
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Membrane / chemistry
Lipid Bilayers / chemistry
Lipids / chemistry*
Liquid Crystals / chemistry
Models, Chemical
Phosphatidylcholines / chemistry
Phospholipids / chemistry
Water / chemistry
Grant Support
ID/Acronym/Agency:
GM 08799/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Lipid Bilayers; 0/Lipids; 0/Phosphatidylcholines; 0/Phospholipids; 7732-18-5/Water

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