Document Detail

The Coapsys device to treat functional mitral regurgitation: in vivo long-term canine study.
MedLine Citation:
PMID:  15052204     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We evaluated the capability of the Myocor Coapsys device (Myocor, Inc, Maple Grove, Minn) to reduce functional mitral regurgitation in a canine model of dilated cardiomyopathy. METHODS: Functional mitral regurgitation with heart failure was induced in 7 dogs by rapid ventricular pacing. The Coapsys device, which consists of anterior and posterior epicardial pads connected by a subvalvular chord, was then implanted. Heart failure was maintained by continued pacing for 8 weeks. Hemodynamic and echocardiographic measurements were performed at pre- and postsizing and after 8 weeks. The Coapsys subvalvular chord was cut to verify that maintenance of valve competency was due to the device. RESULTS: All implants were performed off-pump without atriotomy. Mitral regurgitation was reduced in all animals; mean mitral regurgitation grade was reduced from 2.9 +/- 0.7 to 0.7 +/- 0.8 (P =.00005) and was maintained at 0.8 +/- 0.8 after 8 weeks, without hemodynamic compromise or structural damage to the mitral valve. Mitral regurgitation returned to 3.6 +/- 0.8 (P =.102 versus presizing) after cutting the Coapsys subvalvular chord. CONCLUSION: The Coapsys device consistently and chronically reduced functional mitral regurgitation. This device is in clinical trials in the United States.
Masahiro Inoue; Patrick M McCarthy; Zoran B Popović; Kazuyoshi Doi; Soren Schenk; Hassan Nemeh; Yoshio Ootaki; Michael W Kopcak; Raymond Dessoffy; James D Thomas; Kiyotaka Fukamachi
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  127     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1068-76; discussion 1076-7     Citation Subset:  AIM; IM    
Department of Bioengineering, The Cleveland Clinic Foundation, Ohio 44195, USA.
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MeSH Terms
Aortic Valve Insufficiency / physiopathology,  surgery,  ultrasonography
Cardiomyopathy, Dilated / physiopathology,  surgery,  ultrasonography
Diastole / physiology
Disease Models, Animal
Heart Valve Prosthesis Implantation
Heart Ventricles / physiopathology,  ultrasonography
Heart-Assist Devices*
Mitral Valve Insufficiency / physiopathology*,  surgery*,  ultrasonography
Models, Cardiovascular
Severity of Illness Index
Stroke Volume / physiology
Systole / physiology
Treatment Outcome
Tricuspid Valve Insufficiency / physiopathology,  surgery,  ultrasonography

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