Document Detail

Coagulopathy secondary to vitamin K deficiency in hyperemesis gravidarum.
MedLine Citation:
PMID:  9764659     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperemesis gravidarum is a condition of pregnancy characterized by excessive nausea and vomiting, which can be associated with malnutrition. Vitamin K deficiency is a known complication of malnutrition as well as a known cause of coagulopathy. To date, there is no reported case in the literature of vitamin K deficiency in hyperemesis gravidarum. CASE: A woman at 15 weeks' gestation presented with hyperemesis gravidarum complicated by an episode of severe epistaxis. Investigation revealed coagulopathy secondary to vitamin K deficiency. The coagulopathy resolved after vitamin K replacement, with complete correction of all clotting factors. CONCLUSION: Vitamin K deficiency and coagulopathy should be considered in women with hyperemesis gravidarum who present with a bleeding diathesis. Prophylactic vitamin K replacement should be considered in cases in which hyperemesis is severe and protracted.
J N Robinson; R Banerjee; M P Thiet
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  92     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-02     Completed Date:  1998-11-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
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MeSH Terms
Blood Coagulation Disorders / etiology*
Hyperemesis Gravidarum / complications*
Vitamin K / therapeutic use
Vitamin K Deficiency / complications*,  drug therapy
Reg. No./Substance:
12001-79-5/Vitamin K

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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