Document Detail

Coagulopathy during cardiac arrest and resuscitation in a swine model of electrically induced ventricular fibrillation.
MedLine Citation:
PMID:  21482008     Owner:  NLM     Status:  MEDLINE    
AIMS: Coagulopathy is often present after resuscitation from cardiac arrest but plays an undefined role in the post cardiac arrest syndrome. The aim of this study was to characterize coagulation changes during cardiac arrest and post-resuscitation care in order to direct further focused study.
METHODS: Ventricular fibrillation (VF) was induced electrically in immature male swine, followed by normothermic American Heart Association Advanced Cardiac Life Support and a uniform post-resuscitation goal-directed resuscitation protocol. PT, aPTT, fibrinogen, Thrombelastography (TEG), platelet contractile force (PCF), clot elastic modulus (CEM), and collagen-induced platelet aggregation were compared at baseline, at 8 min of VF, during the 3rd round of chest compressions (CPR), and at 15, 90, 180, and 360 min after return of circulation using repeated measures ANOVA.
RESULTS: 8/18 (44%) animals were resuscitated after 10.9 ± 0.9 min of VF and 7.6 ± 3.4 min of CPR. TEG revealed a significant impairment in clot strength (MA) and clot formation kinetics (K, alpha angle) arising during CPR, followed by a brief prolongation of clot onset times (R) after return of circulation. Both PCF and CEM fell significantly during CPR (PCF by 50%, CEM by 47% of baseline) and platelet aggregation was significantly decreased during CPR. Coagulation changes were partially recovered by 3h of post-resuscitation care.
CONCLUSION: Whole blood coagulation was rapidly impaired during CPR after electrically induced VF in this swine model by impaired platelet aggregation/contractile function and clotting kinetics. Further platelet-specific study is indicated.
Nathan J White; Benjamin Sieu-Hon Leong; Jessica Brueckner; Erika J Martin; Donald F Brophy; Mary A Peberdy; Joseph Ornato; Kevin R Ward
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-08
Journal Detail:
Title:  Resuscitation     Volume:  82     ISSN:  1873-1570     ISO Abbreviation:  Resuscitation     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-12-07     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  925-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Medicine, University of Washington, Seattle, WA, USA.
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MeSH Terms
Blood Coagulation Disorders / blood,  etiology*
Cardiopulmonary Resuscitation / adverse effects*,  methods
Disease Models, Animal
Fibrinogen / metabolism
Heart Arrest / blood,  complications*,  therapy
Heart Rate
Platelet Aggregation
Risk Factors
Ventricular Fibrillation / complications*,  physiopathology,  therapy
Grant Support
Reg. No./Substance:

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