| Coagulopathy during cardiac arrest and resuscitation in a swine model of electrically induced ventricular fibrillation. | |
| | |
MedLine Citation:
|
PMID: 21482008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Coagulopathy is often present after resuscitation from cardiac arrest but plays an undefined role in the post cardiac arrest syndrome. The aim of this study was to characterize coagulation changes during cardiac arrest and post-resuscitation care in order to direct further focused study. METHODS: Ventricular fibrillation (VF) was induced electrically in immature male swine, followed by normothermic American Heart Association Advanced Cardiac Life Support and a uniform post-resuscitation goal-directed resuscitation protocol. PT, aPTT, fibrinogen, Thrombelastography (TEG), platelet contractile force (PCF), clot elastic modulus (CEM), and collagen-induced platelet aggregation were compared at baseline, at 8 min of VF, during the 3rd round of chest compressions (CPR), and at 15, 90, 180, and 360 min after return of circulation using repeated measures ANOVA. RESULTS: 8/18 (44%) animals were resuscitated after 10.9 ± 0.9 min of VF and 7.6 ± 3.4 min of CPR. TEG revealed a significant impairment in clot strength (MA) and clot formation kinetics (K, alpha angle) arising during CPR, followed by a brief prolongation of clot onset times (R) after return of circulation. Both PCF and CEM fell significantly during CPR (PCF by 50%, CEM by 47% of baseline) and platelet aggregation was significantly decreased during CPR. Coagulation changes were partially recovered by 3h of post-resuscitation care. CONCLUSION: Whole blood coagulation was rapidly impaired during CPR after electrically induced VF in this swine model by impaired platelet aggregation/contractile function and clotting kinetics. Further platelet-specific study is indicated. |
| | |
Authors:
|
Nathan J White; Benjamin Sieu-Hon Leong; Jessica Brueckner; Erika J Martin; Donald F Brophy; Mary A Peberdy; Joseph Ornato; Kevin R Ward |
Related Documents
:
|
1290168 - Dibucaine elicits platelet procoagulant activity in factor viii and factor x activation... 6732788 - Presence of platelet-activating factor in blood from humans and experimental animals. i... 12009098 - Investigation of coagulopathy in three cases of tiger snake (notechis ater occidentalis... 6795738 - Characterization of a form of bovine factor viii which does not aggregate human platelets. 22446168 - Hemostatic properties of the fviia analog nn1731. 22507958 - Allium ursinum l.: bioassay-guided isolation and identification of a galactolipid and a... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-08 |
Journal Detail:
|
Title: Resuscitation Volume: 82 ISSN: 1873-1570 ISO Abbreviation: Resuscitation Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-06-06 Completed Date: 2011-12-07 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
|
Languages: eng Pagination: 925-31 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Medicine, University of Washington, Seattle, WA, USA. whiten4@u.washington.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Coagulation Disorders / blood, etiology* Cardiopulmonary Resuscitation / adverse effects*, methods Disease Models, Animal Fibrinogen / metabolism Heart Arrest / blood, complications*, therapy Heart Rate Male Platelet Aggregation Risk Factors Swine Thrombelastography Ventricular Fibrillation / complications*, physiopathology, therapy |
| Grant Support | |
ID/Acronym/Agency:
|
GM008695-09/GM/NIGMS NIH HHS; T32 GM008695/GM/NIGMS NIH HHS; UL1 RR025014/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
9001-32-5/Fibrinogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prognostic indicators and outcome prediction model for patients with return of spontaneous circulati...
Next Document: Severe QTc prolongation under mild hypothermia treatment and incidence of arrhythmias after cardiac ...