Document Detail

Coagulopathy of chronic liver disease.
MedLine Citation:
PMID:  21995407     Owner:  NLM     Status:  In-Data-Review    
To the Editor: In their review article, Tripodi and Mannucci (July 14 issue)(1) present data that suggest a procoagulant imbalance in cirrhosis. Resistance to anticoagulation that is mediated by thrombomodulin(2) and an increased relative risk of venous thromboembolism(3) indicate that patients with cirrhosis do not undergo anticoagulation because of their increased prothrombin time. Consequently, the rationale to administer fresh-frozen plasma to correct the prothrombin time before invasive procedures is debated. One of the invasive procedures that is most frequently performed in patients with decompensated cirrhosis is diagnostic or large-volume paracentesis. Even in patients with elevated values for the international normalized . . .
Francesco Violi; Domenico Ferro; Stefania Basili
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  365     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1452-4     Citation Subset:  AIM; IM    
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