| Coagulopathy of chronic liver disease. | |
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MedLine Citation:
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PMID: 21995405 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To the Editor: In their review article, Tripodi and Mannucci (July 14 issue)(1) present data that suggest a procoagulant imbalance in cirrhosis. Resistance to anticoagulation that is mediated by thrombomodulin(2) and an increased relative risk of venous thromboembolism(3) indicate that patients with cirrhosis do not undergo anticoagulation because of their increased prothrombin time. Consequently, the rationale to administer fresh-frozen plasma to correct the prothrombin time before invasive procedures is debated. One of the invasive procedures that is most frequently performed in patients with decompensated cirrhosis is diagnostic or large-volume paracentesis. Even in patients with elevated values for the international normalized . . . |
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Authors:
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Andrea De Gottardi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The New England journal of medicine Volume: 365 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 1452-4 Citation Subset: AIM; IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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