| Coagulation system activated in Duchenne muscular dystrophy patients with cardiac dysfunction. | |
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MedLine Citation:
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PMID: 16122628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated basic abnormalities of coagulation and fibrinolysis in Duchenne muscular dystrophy (DMD) patients with cardiac dysfunction. Forty seven patients with DMD, aged 13-37 years old, were enrolled. Based on left ventricular ejection fraction (LVEF) results determined by echocardiography, patients were divided into 3 groups: LVEF less than 30% (markedly depressed group), LVEF between 30 and 50% (slightly depressed), and LVEF greater than 50% (normal). We measured serum levels of total fibrin and fibrinogen degradation products (FDP), as well as plasma fibrinogen, thrombin-antithrombin complex (TAT), prothrombin fragment (F1+2), and D-dimer. The levels of TAT and F1+2 in the markedly depressed group were significantly elevated compared with the other groups, whereas FDP, fibrinogen, and D-dimer levels did not differ among the groups. We concluded that activated coagulation is associated with cardiac dysfunction in patients with DMD. |
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Authors:
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Toshio Saito; Yuko Yamamoto; Tsuyoshi Matsumura; Sonoko Nozaki; Harutoshi Fujimura; Susumu Shinno |
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Publication Detail:
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Type: Journal Article Date: 2004-12-15 |
Journal Detail:
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Title: Brain & development Volume: 27 ISSN: 0387-7604 ISO Abbreviation: Brain Dev. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-26 Completed Date: 2005-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 415-8 Citation Subset: IM |
Affiliation:
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Division of Neurology, National Hospital Organization Toneyama National Hospital, 5-1-1 Toneyama, Toyonaka, Osaka 560-8552, Japan. saitot@toneyama.hosp.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antithrombin III Blood Coagulation Disorders / blood, complications* Cardiomyopathy, Dilated / blood, complications*, ultrasonography Coronary Thrombosis / blood, complications* Echocardiography Fibrin Fibrinogen Degradation Products / metabolism Fibrinogen / metabolism Fibrinolysis Humans Male Muscular Dystrophy, Duchenne / blood, complications* Peptide Fragments / blood Peptide Hydrolases / blood Protein Precursors / blood Prothrombin |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Protein Precursors; 0/antithrombin III-protease complex; 0/fibrin fragment D; 72270-84-9/prothrombin fragment 1; 78768-79-3/prothrombin fragment 2; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; 9001-32-5/Fibrinogen; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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