Document Detail

Coagulation system activated in Duchenne muscular dystrophy patients with cardiac dysfunction.
MedLine Citation:
PMID:  16122628     Owner:  NLM     Status:  MEDLINE    
We investigated basic abnormalities of coagulation and fibrinolysis in Duchenne muscular dystrophy (DMD) patients with cardiac dysfunction. Forty seven patients with DMD, aged 13-37 years old, were enrolled. Based on left ventricular ejection fraction (LVEF) results determined by echocardiography, patients were divided into 3 groups: LVEF less than 30% (markedly depressed group), LVEF between 30 and 50% (slightly depressed), and LVEF greater than 50% (normal). We measured serum levels of total fibrin and fibrinogen degradation products (FDP), as well as plasma fibrinogen, thrombin-antithrombin complex (TAT), prothrombin fragment (F1+2), and D-dimer. The levels of TAT and F1+2 in the markedly depressed group were significantly elevated compared with the other groups, whereas FDP, fibrinogen, and D-dimer levels did not differ among the groups. We concluded that activated coagulation is associated with cardiac dysfunction in patients with DMD.
Toshio Saito; Yuko Yamamoto; Tsuyoshi Matsumura; Sonoko Nozaki; Harutoshi Fujimura; Susumu Shinno
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Publication Detail:
Type:  Journal Article     Date:  2004-12-15
Journal Detail:
Title:  Brain & development     Volume:  27     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-26     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  415-8     Citation Subset:  IM    
Division of Neurology, National Hospital Organization Toneyama National Hospital, 5-1-1 Toneyama, Toyonaka, Osaka 560-8552, Japan.
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MeSH Terms
Antithrombin III
Blood Coagulation Disorders / blood,  complications*
Cardiomyopathy, Dilated / blood,  complications*,  ultrasonography
Coronary Thrombosis / blood,  complications*
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinogen / metabolism
Muscular Dystrophy, Duchenne / blood,  complications*
Peptide Fragments / blood
Peptide Hydrolases / blood
Protein Precursors / blood
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Protein Precursors; 0/antithrombin III-protease complex; 0/fibrin fragment D; 72270-84-9/prothrombin fragment 1; 78768-79-3/prothrombin fragment 2; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; 9001-32-5/Fibrinogen; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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