Document Detail

Coagulation studies, factor V Leiden, and anticardiolipin antibodies in 40 cases of cerebral venous thrombosis.
MedLine Citation:
PMID:  8841318     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Cerebral venous thrombosis (CVT) is an infrequent condition with a large variety of causes. However, in 20% to 35% of cases, no cause is found. We studied coagulation parameters, including activated protein C resistance associated with factor V gene mutation (factor V Leiden) and anticardiolipin antibodies, in a large series of patients with CVT with or without identified cause or risk factor. METHODS: Forty patients (30 women and 10 men) aged 19 to 71 years (mean age, 36.2 years) with CVT diagnosed by angiography and/or MRI were studied 1 to 18 years after thrombosis. No known cause was found in 10 idiopathic cases. Coagulation studies included the following tests: fibrinogen, antithrombin, protein C, protein S, plasminogen, anticardiolipin antibodies, activated protein C resistance, and factor V Leiden. RESULTS: Six cases of thrombophilia (15%) were found: 1 protein C deficiency, 1 protein S deficiency, and 4 activated protein C resistance with heterozygous factor V Leiden mutation (10%). Only 1 case (protein S deficiency) was found in the group of 10 patients with idiopathic CVT. In the other 5, there was another cause or risk factor. Three patients (8%) had increased anticardiolipin antibodies: 1 with systemic lupus and 2 with primary antiphospholipid syndrome; 2 of these 3 patients also had factor V Leiden mutation. CONCLUSIONS: Although present in a number of CVT cases, acquired (anticardiolipin) or congenital varieties of thrombophilia (factor V Leiden being the most frequent) are almost invariably associated with other predisposing factors. This suggests that (1) these abnormalities should be looked for in patients with CVT, whether a cause is found or not, and (2) their presence should not deter the search for other potential causes. The detection of such abnormalities has major practical consequences on the long-term management of patients to prevent further thrombotic episodes.
M A Deschiens; J Conard; M H Horellou; A Ameri; M Preter; F Chedru; M M Samama; M G Bousser
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  27     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-15     Completed Date:  1996-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1724-30     Citation Subset:  IM    
Service de Neurologie Hôpital Saint-Antoine, Paris, France.
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MeSH Terms
Antibodies, Anticardiolipin / analysis*
Blood Coagulation*
Blood Coagulation Tests
Cerebral Veins
Drug Resistance
Factor V / genetics*
Intracranial Embolism and Thrombosis / blood*,  genetics*,  immunology
Middle Aged
Protein C / physiology
Protein C Deficiency
Protein S Deficiency / complications
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Protein C; 0/factor V Leiden; 9001-24-5/Factor V
Comment In:
Stroke. 1996 Oct;27(10):1719-20   [PMID:  8841316 ]

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