Document Detail


Coagulation status and complications of pregnancy.
MedLine Citation:
PMID:  15792676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: There is much interest in the relationship between coagulation status and complications of pregnancy. The thrombelastograph (TEG) has been proposed as a useful, inexpensive tool to screen for patients with hypercoagulable states. MATERIALS AND METHODS: We investigated 588 unselected pregnant women at booking, obtaining blood samples for TEG and thrombophilia investigation. Pregnancy outcome data was recorded. RESULTS: We found significant correlations between TEG parameters and the Prothrombin time (PT) and Activated Partial Thromboplastin time (APTT) (p<0.01) and with plasma Antithrombin level (p<0.01). There was no correlation between TEG and other thrombophilic defects (protein C, protein S, Factor V Leiden mutation, Prothrombin G20210A mutation, MTHFR C677T mutation and Lupus Anticoagulant). There was a significant association of TEG parameters with mid-trimester loss (MTL) but not with other adverse pregnancy outcomes. CONCLUSIONS: The correlation between TEG and PT, APTT and antithrombin level supports its value in providing a global measure of haemostasis. Coagulation status at booking is associated with increased risk of MTL but not with complications occurring later in pregnancy.
Authors:
Fiona M Miall; Paramjeet S Deol; Tim A Barnes; Karen Dampier; Christopher C Watson; Christina A Oppenheimer; K John Pasi; Sue R Pavord
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2004-11-05
Journal Detail:
Title:  Thrombosis research     Volume:  115     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
Affiliation:
University Hospitals of Leicester NHS Trust, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Coagulation Tests / instrumentation,  methods
Comorbidity
Female
Great Britain / epidemiology
Humans
Predictive Value of Tests
Pregnancy
Pregnancy Complications / blood,  epidemiology*
Pregnancy Trimester, Third
Prospective Studies
Risk Factors
Thrombelastography / instrumentation,  standards
Thrombophilia / diagnosis*,  epidemiology*,  genetics
Time Factors
Whole Blood Coagulation Time

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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