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Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy.
MedLine Citation:
PMID:  21809018     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy. METHODS: One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured. RESULTS: Fg, F1 + 2, thrombin-antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased. CONCLUSION: Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.
Authors:
H Chen; L Zhou; L Meng; M Liu; J Tan; L Gao; J Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-2
Journal Detail:
Title:  Irish journal of medical science     Volume:  -     ISSN:  1863-4362     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Yanjiang Road 107, Guangdong, Guangzhou, China.
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