Document Detail

Coagulation profiles in hypothyroid and hyperthyroid female patients in Sudan.
MedLine Citation:
PMID:  18813414     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate disturbances in the coagulation system in female patients with thyroid disorders in order to assess the effects of thyroid diseases on coagulation parameters. METHODS: This study was conducted in Khartoum state, the national capital of Sudan from February 2007 and February 2008 The study included 30 patients with clinical hypothyroidism, and 30 patients with sub- clinical hypothyroidism (21 of them were recruited before starting the treatment). Also, the study included 30 patients with clinical hyperthyroidism, 30 with sub-clinical hyperthyroidism, (37 of them were recruited before starting the treatment) and 30 normal individuals as the control group. Prothrombin time (PT), activated partial thromboplastin time, fibrinogen level, and platelets count were performed in patients and control samples. RESULTS: A significantly decrease in PT was observed in hypothyroid patients, and hyperthyroid patients compared to the control group. Activated thromboplastin time was significantly decreased only in hyperthyroid patients, compared to the control group. Moreover, fibrinogen level was significantly increased in hyperthyroid patients compared to hypothyroid patients. CONCLUSION: The study concluded that minor coagulation abnormalities were observed in both subclinical hypo- and hyperthyroidism compared to clinical hypo- and hyperthyroidism. Platelets count was also slightly decreased in both types of the disease. There was no significant effect of the treatment and age of such patients on the measured parameters. The study recommended to screen female patients with hypo- and hyperthyroidism for coagulation defect, to avoid the risk of such complications.
Mohamed S Mohamed-Ali; Rugia O Ahmed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  29     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-24     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1289-93     Citation Subset:  IM    
Department of Hematology, Faculty of Medical Laboratory Sciences, Al-Neelain University, PO Box 12702, Khartoum, Sudan.
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MeSH Terms
Blood Coagulation*
Hyperthyroidism / blood*
Hypothyroidism / blood*

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