| Coagulation and inflammation. Molecular insights and diagnostic implications. | |
| | |
MedLine Citation:
|
PMID: 21152678 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Overwhelming evidence has linked inflammatory disorders to a hypercoagulable state. In fact, thromboembolic complications are among the leading causes of disability and death in many acute and chronic inflammatory diseases. Despite this clinical knowledge, coagulation and immunity were long regarded as separate entities. Recent studies have unveiled molecular underpinnings of the intimate interconnection between both systems. The studies have clearly shown that distinct pro-inflammatory stimuli also activate the clotting cascade and that coagulation in turn modulates inflammatory signaling pathways. In this review, we use evidence from sepsis and inflammatory bowel diseases as a paradigm for acute and chronic inflammatory states in general and rise hypotheses how a systematic molecular understanding of the "inflammation-coagulation" crosstalk may result in novel diagnostic and therapeutic strategies that target the inflammation-induced hypercoagulable state. |
| | |
Authors:
|
S Lipinski; L Bremer; T Lammers; F Thieme; S Schreiber; P Rosenstiel |
Related Documents
:
|
17914358 - Phagocyte-derived catecholamines enhance acute inflammatory injury. 300258 - Pulmonary host defense: coordinated interaction of mechanical, cellular and humoral imm... 8542148 - Effect of a specific neutrophil elastase inhibitor, ono-5046, on endotoxin-induced acut... 8438998 - Hospital-acquired gram-negative pneumonia in critically ill, injured patients. 19479378 - Inside an enigma: do mitochondria contribute to cell death in drosophila? 17914358 - Phagocyte-derived catecholamines enhance acute inflammatory injury. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-09 |
Journal Detail:
|
Title: Hamostaseologie Volume: 31 ISSN: 0720-9355 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8204531 Medline TA: Hamostaseologie Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Prof. Dr. Philip Rosenstiel, Institut für Klinische Molekularbiologie, Christian-Albrechts-Universität, Schittenhelmstr. 12, 24105 Kiel, Germany, Tel. +49/(0)431/597 13 33, Fax +49/(0)431/597 21 96 E-mail: p.rosenstiel@mucosa.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Platelet function testing in clinical diagnostics.
Next Document: New approaches and indications for the analysis of platelet function in cardiology.