Document Detail

Coagulation, fibrinolysis, platelet and kinin-forming systems during toxemia of pregnancy.
MedLine Citation:
PMID:  6652168     Owner:  NLM     Status:  MEDLINE    
The coagulation, fibrinolysis, and platelet and kinin-forming systems were studied during toxemia of pregnancy by multifactorial examinations. In severe toxemia of pregnancy, decreases in extrinsic coagulation factors, platelet, antithrombin III, plasminogen, alpha 2-plasmin inhibitor, and increases in soluble fibrin-monomer complex, fibrin degradation products, beta-thromboglobulin were observed. This suggests that intravascular coagulation, induced probably through the extrinsic pathway and secondary fibrinolysis, is associated with toxemia of pregnancy. Prekallikrein increased during pregnancy but decreased rapidly with onset of labor. The same changes were observed in high molecular weight kininogen, indicating that kinin may be generated, which would contribute to the uterine contraction during labor. The prekallikrein level was significantly low during severe toxemia.
M Maki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biological research in pregnancy and perinatology     Volume:  4     ISSN:  0724-438X     ISO Abbreviation:  Biol Res Pregnancy Perinatol     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302758     Medline TA:  Biol Res Pregnancy Perinatol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  152-4     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation
Platelet Count
Platelet Function Tests
Pre-Eclampsia / blood*
Prekallikrein / analysis
Reg. No./Substance:

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