| Coagulation factor XIII VaI34Leu polymorphism in patients with small vessel disease or primary intracerebral hemorrhage. | |
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MedLine Citation:
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PMID: 15644629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Factor (F) XIII is a transglutaminase which stabilizes fibrin clots by forming cross-links between chains of fibrin. A common Val34Leu polymorphism of FXIII is correlated with the level of activated plasma FXIII. The homozygous 34Val genotype may be associated with an increased risk for thrombosis by forming fibrin fibers more resistant to fibrinolysis. The aim of the study was to investigate the association between the FXIII Val34Leu polymorphism and the risk of ischemic stroke due to small vessel disease (SVD) or the risk of primary intracerebral hemorrhage (PICH). METHODS: 66 patients with SVD stroke and 135 age- and sex-matched controls as well as 64 patients with PICH and their 127 controls were included. The FXIII Val34Leu polymorphism was genotyped using the polymerase chain reaction and restriction enzyme digestion methods. RESULTS: The homozygous 34Val genotype was found significantly more often in patients with SVD stroke than in their controls (62 vs. 42%). On multivariate analysis, the Val/Val genotype was associated with an increased risk of SVD stroke (odds ratio: 2.1, 95% confidence interval: 1.1-3.9). The genotype distribution did not differ significantly between PICH patients and their controls (50 vs. 43%). CONCLUSION: Our results suggest that the Val/Val genotype of FXIII could be associated with an increased risk of SVD stroke. |
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Authors:
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Agnieszka Slowik; Tomasz Dziedzic; Joanna Pera; Denise A Figlewicz; Andrzej Szczudlik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-01-11 |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 19 ISSN: 1015-9770 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-03-08 Completed Date: 2005-04-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 165-70 Citation Subset: IM |
Copyright Information:
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Copyright 2005 S. Karger AG, Basel |
Affiliation:
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Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cerebral Hemorrhage / epidemiology, genetics* Factor XIII / genetics* Female Genetic Predisposition to Disease / epidemiology Genotype Humans Male Middle Aged Polymorphism, Genetic* Risk Factors Stroke / epidemiology, genetics* |
| Chemical | |
Reg. No./Substance:
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9013-56-3/Factor XIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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