Document Detail

Coagulation factor VII and inflammatory markers in patients with coronary heart disease.
MedLine Citation:
PMID:  17581323     Owner:  NLM     Status:  MEDLINE    
To further elucidate the connection between inflammation and factor VII (FVII) taking genetic variation in the FVII locus into account, we have examined 387 patients after myocardial infarction and 387 age-matched and sex-matched healthy control individuals. Circulating levels of C-reactive protein, FVII antigen (FVIIag), activated FVII (FVIIa), fibrinogen and interleukin-6 were analysed and all subjects were genotyped for the Arg353Gln polymorphism in the FVII locus. Plasma concentrations of C-reactive protein, fibrinogen, and interleukin-6 were higher among patients than control individuals. FVIIag was lower in the patient group, but for FVIIa there was no difference between the two groups. Among the inflammatory markers, only C-reactive protein indicated a weak nonlinear association with FVII. No significant difference in frequency of the Gln allele was observed between patients and control individuals but the presence of the Gln allele was associated with lower plasma levels of FVIIag and FVIIa in both groups. The low-grade chronic inflammation seen 3 months after myocardial infarction is not of major importance for the variation in plasma concentration of FVII. The presence of the Gln allele in the Arg353Gln polymorphism in the FVII locus did not differ between patients and control individuals but was associated with lower plasma levels of FVIIag and FVIIa that could have a protective effect against myocardial infarction. To further elucidate these facts, a prospective study should be performed to reduce the risk of a possible selection bias due to coronary heart disease death seen in retrospective case-control studies.
Mattias Ekström; Angela Silveira; Marie Bennermo; Per Eriksson; Per Tornvall
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  18     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Department of Cardiology, Karolinska University Hospital Solna, Karolinska Institutet, Solna, Sweden.
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MeSH Terms
Amino Acid Substitution
Biological Markers / blood
C-Reactive Protein / analysis
Coronary Disease / blood*,  genetics
Factor VIIa / analysis*,  genetics
Fibrinogen / analysis
Inflammation / blood,  genetics
Inflammation Mediators / blood*
Interleukin-6 / blood
Middle Aged
Myocardial Infarction / blood*,  genetics
Polymorphism, Genetic*
Quantitative Trait Loci*
Reg. No./Substance:
0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC VIIa

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