Document Detail


Coagulation changes following vasectomy: a study in primates.
MedLine Citation:
PMID:  97098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty vasectomized rhesus monkeys were tested for changes in coagulation factors that might reflect an increased incidence of thrombosis. The results of tests on these monkeys were compared with results of tests on 18 control rhesus monkeys; there were no significant differences between control and vasectomized animals for any of the parameters tested. One vasectomized animal had increased levels of fibrin monomer in his plasma on repeated samples, but no evidence of thrombosis on postmortem examination.
This study attempted to determine whether fibrin monomer complexes, or other alterations of coagulation factor activities that might predispose to thrombosis, were present in 30 vasectomized Rhesus monkeys that had had bilateral vasectomies 1-11 years earlier. Blood coagulation factors, prothrombin, factors V and VIII, fibrogen, and antithrombin III, are consumed when blood coagulation occurs. If consumption of these factors is in excess of the individual's ability to synthesize them, a decreased concentration results. No significant decreases in activities of any consumable clotting factors were found. If intravascular coagulation is present, certain products of coagulation may be present in the blood even though consumable factors remain normal. Products of intravascular coagulation include fibrin monomer and plasmin digestion products of fibrin. No significant differences in average values of fibrin monomer and fibrin digestion products in control and vasectomized animals were found. 1 animal had increased fibrin monomer, but on postmortem examination, no evidence of intravascular thrombosis was seen.
Authors:
C T Kisker; N J Alexander
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  29     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-09-29     Completed Date:  1978-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-5     Citation Subset:  IM; J    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Coagulation*
Blood Coagulation Tests
Haplorhini
Humans
Macaca mulatta
Male
Vasectomy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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