Document Detail

Coagulation abnormalities and severe intraventricular hemorrhage in extremely low birth weight infants.
MedLine Citation:
PMID:  19757338     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The association between intraventricular hemorrhage (IVH) and coagulation in infants has been a subject of controversy. Only few publications assessing risk factors for development of IVH reported results of coagulation studies. OBJECTIVES: To evaluate the levels of coagulation and fibrinolysis systems in ELBW infants and determine their influence on IVH. PATIENTS AND METHODS: Following IRB approval coagulation status of 38 ELBW infants was evaluated on first and second day of life. Severity of IVH assessed by cerebral ultrasonography was graded according to Papile classification. Newborns were assigned to either Group A--Grade III or IV, or Group B--Grade I-II, or no IVH. RESULTS: Neonates with Grade III/IV IVH had significantly lower plasma Factor VII (FVII) level on first day of life and FVII differed significantly between Groups A and B with sensitivity of 100%, specificity 41% for a cut-off value of< 7%. In Group A there was no improvement of prothrombin and activated partial thromboplastin times on Day 2. A significant decline of platelet count was also observed. CONCLUSIONS: High-grade IVH coincides with severe derangement of coagulation in ELBW infants with FVII level being the most sensitive, it is not clear what the reason for such low FVII concentration is. Further studies are indicated.
Andrzej Piotrowski; Iwona Dabrowska-Wojciak; Marek Mikinka; Wojciech Fendler; Wojciech Walas; Wojciech Sobala; Krzysztof Marek Kuczkowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-17     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  IM    
Department of Anesthesia and Intensive Care, Pediatric University Hospital, Medical University in Lodz, ul. Sporna 36/50, Lodz, Poland.
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MeSH Terms
Apgar Score
Birth Weight / physiology
Blood Coagulation Disorders / blood,  congenital*,  epidemiology*,  ultrasonography
Cerebral Hemorrhage / blood,  congenital*,  epidemiology*,  ultrasonography
Cerebral Ventricles / pathology
Fibrinolysis / physiology
Infant, Extremely Low Birth Weight* / blood
Infant, Newborn
Infant, Premature, Diseases / blood,  epidemiology,  ultrasonography
Platelet Count

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