Document Detail


Coagulation and fibrinolytic indices during the first trimester of pregnancy in women with polycystic ovary syndrome: a preliminary study.
MedLine Citation:
PMID:  23585337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the levels of coagulation and fibrinolytic markers during the first trimester of pregnancy in women with polycystic ovary syndrome (PCOS) and determine the effects of PCOS and obesity on the levels of these hemostatic markers.
METHODS: A cross-sectional study was conducted in Beijing, China, on women with PCOS (n = 50), healthy women (n = 50), pregnant women with PCOS (n = 50), and healthy pregnant women (n = 50) at 12 weeks of pregnancy. Coagulation and fibrinolytic parameters were measured.
RESULTS: The interaction between PCOS and pregnancy appears to exert effects on the activities of coagulation factors VIII and X. The interaction between PCOS and obesity also seems to affect the level of von Willebrand factor.
CONCLUSIONS: Pregnant women with PCOS, especially women who are obese, are observed to be in a more prohemostatic state during the first trimester.
Authors:
Yu Shan; Aiming Wang; Ying Sun; Wen Jiang; Baosen Pang; Zhiyuan An; Xin Du; Wei Wang; Zhongwei Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-12
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  20     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-11     Completed Date:  2014-03-17     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1390-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Biological Markers / blood
Blood Coagulation*
Blood Coagulation Tests
Case-Control Studies
China
Cross-Sectional Studies
Factor VIII / analysis
Factor X / analysis
Female
Fibrinolysis*
Humans
Obesity / blood
Polycystic Ovary Syndrome / blood*,  diagnosis
Pregnancy
Pregnancy Trimester, First / blood*
von Willebrand Factor / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/F8 protein, human; 0/von Willebrand Factor; 9001-27-8/Factor VIII; 9001-29-0/Factor X
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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