| Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus. | |
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MedLine Citation:
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PMID: 23019612 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher organisms remains unclear. Here, we modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of HAdv-FX complex. In vivo genome-wide transcriptional profiling revealed that FX-binding-ablated virus failed to activate a distinct network of NF-κB-dependent early response genes that are activated by HAdv-FX complex downstream of TLR4/MyD88/TRIF/TRAF6 signaling. Our study implicates host factor "decoration" of the virus as a mechanism to trigger an innate immune sensor that responds to a misplacement of coagulation FX from the blood into intracellular macrophage compartments upon virus entry into the cell. |
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Authors:
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Konstantin Doronin; Justin W Flatt; Nelson C Di Paolo; Reeti Khare; Oleksandr Kalyuzhniy; Mauro Acchione; John P Sumida; Umeharu Ohto; Toshiyuki Shimizu; Sachiko Akashi-Takamura; Kensuke Miyake; James W Macdonald; Theo K Bammler; Richard P Beyer; Frederico M Farin; Phoebe L Stewart; Dmitry M Shayakhmetov |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: - ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, University of Washington, Seattle, WA 98195, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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