| Coagulation abnormalities in the trauma patient: the role of point-of-care thromboelastography. | |
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MedLine Citation:
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PMID: 20978993 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Current recommendations for resuscitation of the critically injured patient are limited by a lack of point-of-care (POC) assessment of coagulation status. Accordingly, the potential exists for indiscriminant blood component administration. Furthermore, although thromboembolic events have been described shortly after injury, the time sequence of post-injury coagulation changes is unknown. Our current understanding of hemostasis has shifted from a classic view, in which coagulation was considered a chain of catalytic enzyme reactions, to the cell-based model (CBM), representing the interplay between the cellular and plasma components of clot formation. Thromboelastography (TEG), a time-sensitive dynamic assay of the viscoelastic properties of blood, closely parallels the CBM, permitting timely, goal-directed restoration of hemostasis via POC monitoring of coagulation status. TEG-based therapy allows for goal-directed blood product administration in trauma, with potential avoidance of the complications resulting from overzealous component administration, as well as the ability to monitor post-injury coagulation status and thromboprophylaxis. This overview addresses coagulation status and thromboprophylaxis management in the trauma patient and the emerging role of POC TEG. |
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Authors:
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Eduardo Gonzalez; Fredric M Pieracci; Ernest E Moore; Jeffry L Kashuk |
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Publication Detail:
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Type: Journal Article Date: 2010-10-26 |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: 36 ISSN: 1098-9064 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 723-37 Citation Subset: IM |
Copyright Information:
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© Thieme Medical Publishers. |
Affiliation:
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Department of Surgery, Denver Health Medical Center and University of Colorado School of Medicine, Denver, Colorado, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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