| Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family. | |
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MedLine Citation:
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PMID: 20112293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transcriptional regulation is dependent on layers of interactions between transcription factors and coactivators, controlling the specificity, temporal regulation, and extent to which transcriptional programs are executed. A key issue in the field of transcriptional regulation is to identify structural mechanisms by which transcription factors and coactivators build hierarchical protein assemblies. The basic helix-loop-helix Per-ARNT-Sim domain (bHLH-PAS) family of transcriptional regulators comprises both transcription factors and coactivators, which have different functions despite conserved domain architecture. Within this family, the tandem PAS domains typically mediate dimerization of the transcription factors, while C-terminal transactivation domains facilitate the dynamic interplay between transcription factors and coactivators. However, recent studies have shown that the modular PAS domains play an important role in regulating coactivator recruitment and oligomerization status. In this study, we provide a brief overview of the structural and functional studies that have identified a novel protein interaction interface on PAS domains utilized by both transcription factors and coactivators within the bHLH-PAS family. |
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Authors:
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Carrie L Partch; Kevin H Gardner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of cellular physiology Volume: 223 ISSN: 1097-4652 ISO Abbreviation: J. Cell. Physiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-04-21 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 553-7 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8816, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basic Helix-Loop-Helix Transcription Factors / chemistry*, metabolism* Gene Expression Regulation* Humans Protein Binding Protein Structure, Tertiary Trans-Activators / metabolism* Transcription, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
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CA130441/CA/NCI NIH HHS; GM081875/GM/NIGMS NIH HHS; R01 GM081875-08/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors; 0/Trans-Activators |
| Comments/Corrections | |
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