| Co-selection in immune network theory and in AIDS pathogenesis. | |
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MedLine Citation:
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PMID: 7806268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Co-selection is a term used to denote the mutual positive selection of individual members from within two diverse populations, such that selection of members within one population is dependent on interaction with (recognition of) one or more member(s) within the other population. Co-selection is a recurring theme of the idiotypic network model that my colleagues and I have developed. This paper discusses the role that co-selection plays in basic symmetrical network theory and in a network model that resolves the I-J paradox. It proposes that co-selection of helper T cells and HIV variants plays a role in the pathogenesis of AIDS. The AIDS model involves a role for the T cell receptor in the infection of T cells. Finally, a way in which a co-selection process may potentially be used in the prevention and therapy of harmful forms of immunity is described. |
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Authors:
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G W Hoffmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunology and cell biology Volume: 72 ISSN: 0818-9641 ISO Abbreviation: Immunol. Cell Biol. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-01-30 Completed Date: 1995-01-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8706300 Medline TA: Immunol Cell Biol Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 338-46 Citation Subset: IM; X |
Affiliation:
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Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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etiology*,
immunology Animals Autoimmunity CD8-Positive T-Lymphocytes / immunology Cercopithecus aethiops / immunology HIV / genetics, isolation & purification, pathogenicity* HIV Antibodies / immunology HLA Antigens / immunology Humans Models, Biological* Mutation Pan troglodytes / immunology Receptors, Antigen, T-Cell / physiology Selection, Genetic* Simian Acquired Immunodeficiency Syndrome / immunology Simian immunodeficiency virus / immunology T-Lymphocyte Subsets / immunology* T-Lymphocytes, Helper-Inducer / immunology |
| Chemical | |
Reg. No./Substance:
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0/HIV Antibodies; 0/HLA Antigens; 0/Receptors, Antigen, T-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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