Document Detail

Co-ordinate expression of Th1/Th2 phenotypes in maternal and fetal blood: evidence for a transplacental nexus.
MedLine Citation:
PMID:  22718606     Owner:  NLM     Status:  In-Data-Review    
Abstract If maternal atopy and environmental exposure affect prenatal Th cell development, the maternal and fetal immune systems should display common Th1/Th2 phenotypes. To test this hypothesis, we studied maternal and neonatal blood samples from mothers with total serum IgE <300 IU/mL. Basal levels of IFN-γ, IL-4, and eotaxin in paired maternal and fetal sera were tightly correlated. Polyclonal T cell activation in vitro by Staphylococcal exotoxin B induced co-ordinate IFN-γ production from paired maternal and fetal mononuclear cells, accompanied by co-ordinate increases in activated CD4+CD69+ cells that display the CCR4+Th2 and CXCR3+ Th1 phenotypes. Maternal and fetal CD4+CXCR3+ T cells were subsequently identified as the major producers of IFN-γ. The data established that a transplacental nexus exists during normal pregnancy and that fetal Th cell responses may be biased by the maternal immune system.
Doris B Tse; Bruce K Young
Related Documents :
11236046 - Prediction of hyperbilirubinaemia in the healthy term newborn.
18681836 - Can neonatal myasthenia gravis be predicted?
21116666 - Primary care physician's attitudes and practices regarding antidepressant use during pr...
21538816 - Diabetic embryopathy: a role for the epigenome?
22042166 - Lower urinary tract symptoms in primiparous women before and during pregnancy.
710596 - Failures following fimbriectomy: a further report.
Publication Detail:
Type:  Journal Article     Date:  2012-01-06
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  40     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Racial disparities in maternal hemoglobin concentrations and pregnancy outcomes.
Next Document:  Developmental delay in hypoxia-induced HO-1 expression predisposes to gut injury.