Document Detail

Co-occurrence of periodic alternating and pendular seesaw nystagmus in blindness.
MedLine Citation:
PMID:  19615695     Owner:  NLM     Status:  MEDLINE    
Even though pendular seesaw nystagmus (PSN) or periodic alternating nystagmus (PAN) has been reported in blind persons, the co-occurrence of PSN and PAN has not been described. A 69-year-old woman with progressive visual loss to only light perception in both eyes showed PSN with a conjugate torsional component and the vertical components in the opposite directions in both eyes. In complete darkness, she also exhibited PAN in addition to PSN. PSN remained unchanged in darkness. The rest of the neurological examination, testing for mitochondrial mutations of Leber's hereditary optic neuropathy, fluorescent angiography, electroretinogram, and brain MRI were normal except for bilateral optic atrophy. Deprivation of the visual inputs, which are required to calibrate normal eye motion, may produce various ocular motor abnormalities in blindness. Although the co-occurrence of PSN and PAN in our patient with visual loss indicates a common etiology, the different effects of darkness on nystagmus intensity suggest a distinct pathomechanism.
Seong-Hae Jeong; Jeong-Min Hwang; Ji Soo Kim
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-16
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  285     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-09     Completed Date:  2010-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  257-8     Citation Subset:  IM    
Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea.
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MeSH Terms
Blindness / complications*,  pathology*
Eye / pathology
Eye Movement Measurements
Neurologic Examination
Nystagmus, Pathologic / complications*,  pathology*

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