Document Detail

Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl.
MedLine Citation:
PMID:  16825914     Owner:  NLM     Status:  MEDLINE    
We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.
Valerio Nobili; Matilde Marcellini; Rita Devito; Donatella Comparcola; Sandro Vento
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  18     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-07     Completed Date:  2007-04-03     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  927-9     Citation Subset:  IM    
Department of Liver Diseases, Bambino Gesù Children's Hospital, Rome cSection of Infectious Diseases, Italy.
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MeSH Terms
Hepatitis B, Chronic / complications*,  diagnosis,  ethnology
Hepatitis, Autoimmune / complications*,  diagnosis,  ethnology
Senegal / ethnology

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