Document Detail


Co-occurrence of Parkinson's disease with progressive supranuclear palsy.
MedLine Citation:
PMID:  11935271     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are distinct neurodegenerative disorders. We describe an 81-year-old woman with 3 years of progressive gait unsteadiness, frequent falls, and mild cognitive dysfunction, all considered clinically to be an early fronto-temporal neurodegenerative disorder. She died of an acute myocardial infarction. Examination of her brain revealed alpha-synuclein- and tau-positive inclusions diagnostic of PD and PSP. Immunoelectron microscopy and Western blot analysis confirmed combined PD/PSP. This case provides strategies for the reliable molecular validation of concomitant PD and PSP, and demonstrates the utility of these techniques in patients with atypical clinical presentations.
Authors:
Alexander R Judkins; Mark S Forman; Kunihiro Uryu; David A Hinkle; Arthur K Asbury; Virginia M-Y Lee; John Q Trojanowski
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2002-01-17
Journal Detail:
Title:  Acta neuropathologica     Volume:  103     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-05     Completed Date:  2002-06-21     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  526-30     Citation Subset:  IM    
Affiliation:
Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Brain / metabolism,  pathology*,  ultrastructure
Female
Humans
Immunohistochemistry
Lewy Bodies / metabolism,  pathology,  ultrastructure
Microscopy, Electron
Nerve Tissue Proteins / metabolism
Neurites / metabolism,  pathology,  ultrastructure
Neurons / metabolism,  pathology*,  ultrastructure
Parkinson Disease / complications*,  pathology*,  physiopathology
Protein Isoforms / metabolism
Supranuclear Palsy, Progressive / complications*,  pathology*,  physiopathology
Synucleins
Trinucleotide Repeat Expansion / genetics
alpha-Synuclein
tau Proteins / metabolism
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Protein Isoforms; 0/SNCA protein, human; 0/Synucleins; 0/alpha-Synuclein; 0/tau Proteins

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