Document Detail

Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients.
MedLine Citation:
PMID:  19303374     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is performed in a large cohort of CF patients. METHODS: Transglutaminase-IgA (TGA), endomysium-IgA (EMA) and total IgA in serum were measured in 790 CF patients (48% females, 86% with pancreatic insufficiency). Six patients were diagnosed with CD prior to the study, all receiving a gluten-free diet. Patients with elevated TGA (>50 Units/mL) and a positive EMA test were offered a gastroscopy obtaining mucosal biopsies from the duodenum. RESULTS: Four new cases of CD were diagnosed. Two additional patients had positive serological tests, but normal biopsies. In total, 10 cases of CD (1.2%, 1:83) indicate a prevalence rate about three times higher than the general prevalence of CD in Norway and Sweden. No CD patients were detected in the Danish CF cohort. Patients diagnosed with untreated CD reported symptoms typical of both CF and CD (poor weight gain, loose and/or fatty stools, fatigue, irritability, abdominal pain). They improved after introduction of a gluten-free diet. CONCLUSIONS: Systematic screening for CD in a Scandinavian cohort of CF patients revealed a higher prevalence of CD than in the general population. Clinical signs of CD are difficult to differentiate from CF with malabsorption, and patients may go undiagnosed for a long time. In a population where CD is common we recommend screening for CD in patients with CF.
G Fluge; H V Olesen; M Gilljam; P Meyer; T Pressler; O T Storrösten; F Karpati; L Hjelte
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-03-19
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  8     ISSN:  1873-5010     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  198-202     Citation Subset:  IM    
Department of Pediatrics, Haukeland Univ. Hospital, Bergen, Norway.
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MeSH Terms
Celiac Disease / blood,  epidemiology*
Child, Preschool
Cross-Sectional Studies
Cystic Fibrosis / blood,  epidemiology*
Immunoglobulin A / blood
Middle Aged
Scandinavia / epidemiology
Young Adult
Reg. No./Substance:
0/Immunoglobulin A

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