| Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients. | |
| | |
MedLine Citation:
|
PMID: 19303374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is performed in a large cohort of CF patients. METHODS: Transglutaminase-IgA (TGA), endomysium-IgA (EMA) and total IgA in serum were measured in 790 CF patients (48% females, 86% with pancreatic insufficiency). Six patients were diagnosed with CD prior to the study, all receiving a gluten-free diet. Patients with elevated TGA (>50 Units/mL) and a positive EMA test were offered a gastroscopy obtaining mucosal biopsies from the duodenum. RESULTS: Four new cases of CD were diagnosed. Two additional patients had positive serological tests, but normal biopsies. In total, 10 cases of CD (1.2%, 1:83) indicate a prevalence rate about three times higher than the general prevalence of CD in Norway and Sweden. No CD patients were detected in the Danish CF cohort. Patients diagnosed with untreated CD reported symptoms typical of both CF and CD (poor weight gain, loose and/or fatty stools, fatigue, irritability, abdominal pain). They improved after introduction of a gluten-free diet. CONCLUSIONS: Systematic screening for CD in a Scandinavian cohort of CF patients revealed a higher prevalence of CD than in the general population. Clinical signs of CD are difficult to differentiate from CF with malabsorption, and patients may go undiagnosed for a long time. In a population where CD is common we recommend screening for CD in patients with CF. |
| | |
Authors:
|
G Fluge; H V Olesen; M Gilljam; P Meyer; T Pressler; O T Storrösten; F Karpati; L Hjelte |
Related Documents
:
|
1783084 - Inherited factors in diffuse bronchiectasis in the adult: a prospective study. 11327394 - Chronic fatigue syndrome following a toxic exposure. 18554694 - Cystic dysplasia of testis associated with ectopic ureter causing chronic orchalgia. 12357484 - Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in ... 22938934 - Imaging of thyrotoxicosis. 21532294 - The relationship between echocardiographic parameters and brain natriuretic peptide lev... |
Publication Detail:
|
Type: Journal Article; Multicenter Study Date: 2009-03-19 |
Journal Detail:
|
Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: 8 ISSN: 1873-5010 ISO Abbreviation: J. Cyst. Fibros. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-04 Completed Date: 2009-07-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 198-202 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Haukeland Univ. Hospital, Bergen, Norway. gjermund.fluge@pedi.uib.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Celiac Disease / blood, epidemiology* Child Child, Preschool Comorbidity Cross-Sectional Studies Cystic Fibrosis / blood, epidemiology* Female Humans Immunoglobulin A / blood Infant Male Middle Aged Prevalence Scandinavia / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1...
Next Document: Predicting liver failure following major hepatectomy.