| Co-morbidity and cardiovascular risk factors in adult growth hormone deficiency following treatment for Cushing's disease or non-functioning pituitary adenomas during childhood. | |
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MedLine Citation:
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PMID: 22258111 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Cushing's disease (CD) and non-functioning pituitary adenoma (NFPA) are rare in paediatric patients. The aim of this study was to describe long-term consequences in adults with GH deficiency (GHD) treated for CD or NFPA during childhood.Design, patients and methods: This was a retrospective analysis of data from KIMS (Pfizer International Metabolic Database). Background characteristics, anthropometry and co-morbidity were studied in 47 patients diagnosed with childhood-onset (CO)-CD and 62 patients with CO-NFPA. Data from 100 ACTH-sufficient patients with CO-Idiopathic hypopituitarism (CO-Idio) were used for comparison. Cardiovascular risk profile was analysed at baseline and at one year on GH treatment in a subgroup of patients not receiving GH treatment at study entry (17 CO-CD; 24 CO-NFPA; 55 CO-Idio).Results: The median age at diagnosis of pituitary tumour was 14.0 years (range 10-17) in CO-CD and 13.7 (range 8-17) in CO-NFPA. In addition to GHD, 41% of CO-CD had 3 or 4 other pituitary hormone deficiencies compared to 78% of CO-NFPA (P <0.001). Of CO-CD patients, 89% had height SDS lower than 0 compared to 61% of CO-NFPA patients (P = 0.002). Hypertension was more common in CO-CD compared with CO-Idio (23 % vs. 9%; P = 0.018). At one year on GH treatment total- and LDL-cholesterol decreased significantly in CO-CD but not in CO-NFPA.Conclusion: Adult patients with GHD following treatment for paediatric CD and NFPA have long-term adverse consequences. Despite more severe hypopituitarism in CO-NFPA, patients with CO-CD have more frequently compromised final stature. |
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Authors:
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Oskar Ragnarsson; Charlotte Hoybye; Peter J Jonsson; Ulla Feldt-Rasmussen; Gudmundur Johannsson; Beverly Biller; Maria Koltowska-Haggstrom |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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O Ragnarsson, Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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